Vol. 7, Issue 1, Part A (2025)

Hypothyroid happens when thyroid gland is underactive. This can exist at any age, but the risk raises as you become older and it is most generally promoted via genetics. thyroid gland is hypoactive, making less thyroid hormone. These hormones regulate the body’s energy balance and metabolism. Iron is very important in maintaining many body functions, including the production of hemoglobin, the molecule in your blood that carries oxygen. Iron is also necessary to maintain healthy cells, skin, hair, and nails. Iron deficiency is very common, especially among women and in people who have a diet that is low in iron. There are several reports suggesting interrelation between iron deficiency anemia with thyroid dysfunction. This study was instituted to examine the influence of thyroid hormones in hypothyroidism states on the levels of TIBC, Hepcidin and Ferritin; in comparison with control group. Also, to study the correlation of serum TIBC and Ferritin with thyroid hormones in hypothyroidism. The present study included 196 Iraqis female patients for hypothyroidism with age ranged between (20-50) years and 100 healthy controls with same age ranged. Serum samples were collected from Tikrit Teaching Hospital, from January 2024 to March 2024. This study is conducted to investigate the relationship between hypothyroidism and iron deficiency anemia in female Iraqi women as well as knowing the relationship between hepcidin, ferritin, and TBIC and the effect of their concentrations on both diseases. Thyroid hormones (TSH, T₄ and T₃) were determined by using the ELFA technique. The level of Hb was determined by a digital Hb Reader instrument. Detection of Total iron binding capacity (TIBC), Ferritin and Hepcidin levels in the serum were determined by an enzyme linked immunosorbent assay (ELISA) kits. The results showed a significant decrease in the levels of Hemoglobin, Ferritin, TIBC, and Hepcidin in patients with hypothyroidism and iron deficiency anemia for patients group compared to healthy subjects. This study proved that there is a relationship between hypothyroidism and iron deficiency anemia, through the results that showed a significant positive correlation between levels of T₃, T₄ and the levels of both Ferritin and TIBC.